Experiments with Induced Bacteriuria, Vesical Emptying and Bacterial Growth on the Mechanism of Bladder Defense to Infection

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Abstract
The study was carried out to determine some of the resistance mechanisms of the bladder to infection. It was shown that urine obtained from healthy subjects was as good a culture medium as broth. The effect of emptying of the bladder was studied by using a flask into which the subject voided. E. coli was introduced, and the flask was maintained at approximate body temperature. Prior to each voiding the flask was emptied, and bacterial counts were carried out at intervals. Repeated emptying of the flask did not completely remove all bacteria, but markedly restricted their proliferation. Introduction of E. coli into the bladder of healthy subjects did not result in proliferation of the organism and infection. It is suggested that this antibacterial mechanism, operative in the bladder in vivo, together with its empting contribute to natural resistance to infection.

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