Systematic overview of co-proxamol to assess analgesic effects of addition of dextropropoxyphene to paracetamol

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Abstract
Key messages Combinations of paracetamol with centrally acting analgesics are widely used, accounting for 73% of all prescriptions for paracetamol in a recent hospital survey in the United KingdomThe combination of paracetamol (650 mg) with dextropropoxyphene hydrochloride (32.5 mg) is particularly popularIn both head to head and indirect comparisons of paracetamol and the combination, the combination was no better than paracetamol on its ownSince the total number of patients in the few published head to head comparisons was modest, small differences in effect cannot be excluded but these are unlikely to be of clinical importance Key messages Combinations of paracetamol with centrally acting analgesics are widely used, accounting for 73% of all prescriptions for paracetamol in a recent hospital survey in the United KingdomThe combination of paracetamol (650 mg) with dextropropoxyphene hydrochloride (32.5 mg) is particularly popularIn both head to head and indirect comparisons of paracetamol and the combination, the combination was no better than paracetamol on its ownSince the total number of patients in the few published head to head comparisons was modest, small differences in effect cannot be excluded but these are unlikely to be of clinical importance

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