Differences in Serum Complement Activity among Inbred Strains of Mice

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Abstract
Summary: Variation in complement activity among inbred strains of mice has been confirmed. In addition, evidence is presented that sera from Balb/cAnN, C57BL/10ScN, B10·D2/Sn “new,” B10·D2/Sn “old,” DBA/2JN and C57BL/6JN have C′1, C′4 and C′2 activities and that differences in C′ titer, in part, may be due to variation in C′3 complex activity. Sera from Balb/cAnN, C57BL/10ScN, and B10·D2/Sn “new” males contain significantly greater C′ and C′3 complex activity than sera from females of the same strain.