VACTERL-ASSOCIATION

  • 1 January 1984
    • journal article
    • research article
    • Vol. 32  (2) , 75-96
Abstract
The so-called 89 VACTERL cases, i.e., 3 or more combinations of vertebral abnormalities (V), anal atresia (A), cardial abnormalities (C), tracheo-esophageal fistula and/or esophageal atresia (TE), renal agenesis and dysplasia (R), limb defect (mainly radial-type reduction or polydactyly) (L) were evaluated in the material of the Hungarian Congenital Malformation Register, 1970-1980. The separation of true VACTERL cases (without other major congenital abnormalities) and mixed VACTERL cases (with other major congenital abnormalities) seemed to be necessary. The latter may be a manifestation of several recognized syndromes. The VACTERL-association, i.e., 3 or more closely defined VACTERL-type abnormalities without other major abnormalities may, however, present a distinct congenital abnormality entity because: the combination of VACTERL-type abnormalities is much higher than the expected one; the majority of cases could not be identified as other multiple congenital abnormality entities; and it has some epidemiological characteristics (e.g. male preponderance).

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