Thromboplastin (factor III) activity in human monocytes induced by immune complexes
- 1 June 1982
- journal article
- research article
- Published by Wiley in European Journal of Clinical Investigation
- Vol. 12 (3) , 229-234
- https://doi.org/10.1111/j.1365-2362.1982.tb00997.x
Abstract
Immune complexes induced the synthesis of apoprotein III, the protein component of tissue thromboplastin (tissue factor) in human monocytes cultured in vitro. The response was maximal (11.1 .+-. 1.7-fold increase (mean .+-. SEM [standard error of mean]) when immune complexes were found at antigen/antibody equivalence. Immune complexes formed with the antigen-binding fragments (F(ab'')2) of Ig induced a 4.7 .+-. 1.4-fold activity increase, suggesting that another signal mechanism in addition to the Fc-receptor may be involved.Keywords
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