IMMEDIATE HEMODYNAMIC EFFECTS OF ISOPROTERENOL
- 1 January 1963
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry and Physiology
- Vol. 41 (1) , 1949-1953
- https://doi.org/10.1139/y63-221
Abstract
Subcutaneous injection of 40 mg/kg isoproterenol is followed within 2 minutes by a fall in blood pressure and peripheral resistance, by tachycardia, and by an increase in cardiac output. It seems likely that these hemodynamic changes are a consequence of a direct action of isoproterenol on the myocardium. Isoproterenol also causes a significant increase in the oxygen consumption of the rats. The increased oxygen demand of the tissues may play a role in maintaining the hemodynamic changes for periods of more than an hour after isoproterenol. Signs of histological damage in the myocardium begin to appear without affecting the function of the cardiovascular system, as measured by the tests used.Keywords
This publication has 3 references indexed in Scilit:
- HEMODYNAMICS DURING THE ACUTE PHASE OF MYOCARDIAL DAMAGE CAUSED BY ISOPROTERENOLCanadian Journal of Biochemistry and Physiology, 1962
- Effects of isoproterenol on cardiac output and renal function in congestive heart failureAmerican Heart Journal, 1961
- Cardiac Output in Rats During the Development of Cardiac HypertrophyCirculation Research, 1958