Isozymes of rodent 5?-nucleotidase: evidence for two independent structural loci Umph-1 and Umph-2
- 1 January 1983
- journal article
- Published by Wiley in Annals of Human Genetics
- Vol. 47 (1) , 9-17
- https://doi.org/10.1111/j.1469-1809.1983.tb00965.x
Abstract
Two distinct isozymes (UMPH-1 and UMPH-2) which hydrolyse pyrimidine 5'-nucleotides have been identified in mouse, rat and Chinese hamster tissues. One of these, UMPH-1 appears to be specific for pyrimidine 5'-nucleotides, whereas the other, UMPH-2 has a broader substrate specificity. UMPH-1 and UMPH-2 show differences in their expression in different tissues. The evidence suggests that UMPH-1 and UMPH-2 are coded by distinct structural gene loci, Umph-1 and Umph-2. These isozymes have not been identified in man, and it is suggested that they may have overlapping electrophoretic mobility.Keywords
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