Influenza Immunization

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Abstract
The 437 residents (average age 78.3 years) and 203 employees (average age 40.0 years) of a retirement community were the subjects in a clinical study comparing immunological effectiveness and reactogenicity of two monovalent Hong Kong influenza vaccines—one a conventional, intact virus vaccine and the other a vaccine prepared from ethyl ether extracted influenza virus antigens. Vaccine pyrogenicity was virtually eliminated by ether treatment, and local and systemic subjective reactions in the antigen vaccinees were one-half to one-fourth as frequent as in the conventional vaccine group. The vaccines were of equal immunogenicity in both populations; however, resident serologic response greatly exceeded employee response presumably because of a youthful experience with a Hong Kong-like virus. Although the community members mingled freely with the general population during the Hong Kong epidemic, no influenzalike disease was observed.

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