On the defect of synthesis ceruloplasmin in the liver polyribosomes in Wilson's disease

1 October 1975

journal article
research article
Published by Springer Nature in Biochemical Genetics

Vol. 13 (9-10) , 533-550
https://doi.org/10.1007/bf00484913

Abstract

Comparative immunochemical analysis of ceruloplasmin-synthesizing polyribosomes in liver biopsies from control subjects and homozygous carriers of the Wilson's mutation was performed. According to I¹²⁵-antibody binding data, the amount of ceruloplasmin-forming liver polysomes in patients with Wilson's disease was 10–20 times lower than that in non-Wilson patients. Correspondingly, the pulse labeling of ceruloplasmin polypeptides was decreased severalfold in the cell-free liver preparations from patients with Wilson's disease.

Keywords

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