Effects of triazolam on conditioned behavior in rats

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Abstract
The effects of triazolam on conditioned behavior were investigated and compared with diazepam in rats. The active conditioned avoidance response of the rat in a shuttle box was inhibited by triazolam and diazepam only at large doses. The passive avoidance response in a step-down method was not affected by either triazolam or diazepam, but was markedly suppressed by chlorpromazine. The low rate response of hypothalamic self-stimulation behavior was markedly increased by triazolam at oral doses ranging from 2-40 mg/kl, but was suppressed at doses over 80 mg/kg. The high rate response was unaffected by triazolam even at doses of 40-180 mg/kg. The low rate response was increased by diazepam at doses of 1-10 mg/kg and was suppressed at 80 mg/kg. The high rate response was reduced by diazpam at 180 mg/kg. In the conflict situation of the rat subjected to food reward and foot-shock punishment, the lever press response in the unpunished period was reduced by triazolam at doses of 1-5 mg/kg, whereas that in the punished period was markedly increased. Similar effects were observed with diazepam at doses of 15-20 mg/kg. Triazolam appeared to be 10-15 times more potent than diazepam in this anticonflict effect. Triazolam appeared to be a potent antianxiety agent.

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