Inducibility of human β-interferon gene in mouse L-cell clones
- 1 June 1982
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 297 (5868) , 650-654
- https://doi.org/10.1038/297650a0
Abstract
Transfer of a 36-kilobase piece of human DNA containing the .beta.-interferon (IFN-.beta.) gene into mouse Ltk- cells leads to transient expression of human interferon even without an exogenous inducer. A low level of human interferon expression is also found in most stable clones containing the transferred DNA. With double-stranded RNA or Newcastle disease virus (NDV) as inducer, human interferon expression is greatly increased. The induced transcript is identical to normal human IFN-.beta. mRNA. Neighboring genes contained on the transferred DNA are co-induced but are not essential for the production of human interferon in mouse L cells.This publication has 34 references indexed in Scilit:
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