A Relationship between Microdosimetric Spectra and Cell Survival for High-LET Irradiation
- 1 January 1991
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology
- Vol. 59 (2) , 447-457
- https://doi.org/10.1080/09553009114550401
Abstract
A method of calculating cell survival from microdosimetric spectra for high-LET radiations and exponential cell survival is discussed. The basis of the calculation is that a cell nucleus receiving a specific dose D has a probability of survival of exp(−D/D0), where D0, the specific lethal dose, is assumed to be independent of cell size and shape. A relationship between specific lethal dose and mean lethal dose is derived. This approach gives the result that mean lethal dose is sensitive to both cell size and shape (cells with disc-shaped and spherical nuclei are treated) and therefore its use as an indicator of cell sensitivity at high LET must be viewed with caution.Keywords
This publication has 2 references indexed in Scilit:
- Hit-Size Effectiveness Theory Applied to High Doses of Low LET Radiation for Pink Mutations in TradescantiaRadiation Protection Dosimetry, 1985
- An Alternative to Absorbed Dose, Quality, and RBE at Low ExposuresRadiation Research, 1985