Possible Linkage between α-Haptoglobin (Hp) and Depression Spectrum Disease

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Abstract
Depression spectrum disease is an unipolar depressive illness in which at least 1 member of the family has unipolar depression and at least 1 other 1st degree relative has alcoholism and/or antisocial personality. Depression spectrum disease human families [14] were studied. Assuming that variability in age of onset was environmentally caused and log normally distributed, segregation analysis showed that the data were compatible with the dichotomy of affected vs. not affected due to an autosomal dominant gene. A simple environmental hypothesis in which the transmission of the illness did not depend upon parental type was rejected (P < 0.001). Linkage analysis was performed by the method of maximum likelihood, taking the best fitting Mendelian model found in the segregation analysis. Virtually no evidence of linkage between depression spectrum disease and C3 [ 3rd complement component] was found, but suggestive evidence (lod score = 1.03) of linkage between depression spectrum disease and .alpha.-haptoglobin was seen. Both of these linkages were previously suggested by significant results in sib-pair analyses.

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