Antigenic marker on a functional subpopulation of B cells, controlled by the I-A subregion of the H-2 complex.

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Abstract
CBA/N mice have an X-linked recessive defect that results in the absence of a subpopulation of B [bone marrow-derived] cells carrying the Lyb3 surface marker. This marker was previously shown to be present on a mature subset of B cells in all mouse strains. The Lyb3+ B cell population in C57BL/6 mice was further analyzed. This subset of B cells selectively expresses a surface marker controlled by the I-A subregion of the H-2 complex. A cytotoxic antiserum recognizing this marker was raised by immunizing defective (CBA/N .times. C57BL/6)F1 .male. mice with C57BL/6 spleen cells. This antiserum also contained noncytotoxic, non-strain-restricted anti-Lyb3 antibodies. The possible functional relevance of this surface marker is discussed.

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