Role of orthophosphate concentration in the regulation of ribose phosphate synthesis and purine metabolism in Ehrlich ascites tumor cells
- 1 August 1977
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry
- Vol. 55 (8) , 834-840
- https://doi.org/10.1139/o77-123
Abstract
Concentrations of intracellular orthophosphate were determined in Ehrlich ascites [mouse] tumor cells incubated with glucose, inosine, or uridine in media of different orthophosphate concentration. The effects of orthophosphate concentration on the accumulation of lactate and phosphoribosyl pyrophosphate and concentrations of ribose-1-phosphate and ribose-5-phosphate in tumor cells incubated with glucose were also determined. The phosphorolysis of inosine and the rate of catabolism of ATP in cells incubated with 2-deoxyglucose were also infleunced by the orthophosphate concentration of the medium.This publication has 2 references indexed in Scilit:
- The effect of washing procedures on the phosphate metabolism of Ehrlich ascites-tumour cellsBiochemical Journal, 1963
- THE EFFECTS OF ADENINE AND GLUCOSE ON SYNTHESIS OF NUCLEOTIDES BY EHRLICH ASCITES CARCINOMA CELLS IN VITROCanadian Journal of Biochemistry and Physiology, 1962