Nasal Absorption of CsCl, SrCl2, BaCl2 and CeCl3 in Syrian Hamsters

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Abstract
Absorption of CsCl, SrCl2, BaCl2 and CeCl3 deposited on nasal membranes directly into the general circulation was studied in Syrian hamsters and compared with gastrointestinal tract absorption. More than 50 % of the cesium, strontium and barium was absorbed directly from the nasal membranes but less than 4 % of the cerium. For all isotopes, nasal absorption was approximately equal to or greater than gastrointestinal absorption during the first 4 hr after administration. This study emphasized the importance of direct nasal absorption of deposited materials in inhalation toxicity evaluations especially with readily soluble aerosols having mass median aerodynamic diameters greater than 5 μm when nasopharyngeal deposition predominates.

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