EFFECTS OF HYPERTHERMIA ON PRIMARY AND METASTATIC TUMOR-GROWTH AND HOST IMMUNE-RESPONSE IN RATS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 38  (3) , 498-502
Abstract
A hot water bath was used to heat locally a metastasizing [mammary] carcinoma in Wistar/Furth rats. Applying heat such that intratumor temperature is maintained at a mean value of 42.3.degree. C for two 90-min sessions results in decreased growth of the primary tumor as well as distant metastases. Heating the primary tumor for only one 90-min session or heating the leg contralateral to the tumor-bearing limb had no effect on the growth rate of the primary tumor or metastases. Heat therapy has no detrimental effect on the spleen cell-mediated tumor immune response of rats as tested by an in vitro lymphocytotoxicity assay 1 day later. Heating isolated spleen cells to similar temperatures in vitro reduces their capacity for in vitro tumor cell killing.

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