HORMONE AND ELECTROLYTE STUDIES OF PATIENTS WITH HYPERADRENOCORTICAL SYNDROME (CUSHING'S SYNDROME)1

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Abstract
Benzene extracts of the blood of 3 patients with Cushing''s syndrome prolonged the lives of adrenalectomized rats beyond the survival period of untreated controls. The "cortin-effect" of 1 cc. of blood was equivalent to 4 to 6 gm. of fresh adrenal tissue. The extract of urine of one of these patients showed a similar effect. Na and K levels in the serum and the urinary excretion of these electrolytes in patients with Cushing''s syndrome showed a shift from the normal which is diametrically opposite that found in adrenal insufficiency.