COMPARISON OF THE RESPIRATORY EFFECTS OF ICI 35 868 AND THIOPENTONE IN THE RABBIT

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Abstract
The effects of thiopentone and ICI 35 868 on minute volume, respiratory frequency, tidal volume and arterialized venous Pco2, pH and standard bicarbonate have been compared in the rabbit. ICI 35 868 has two to three times the potency of thiopentone, but equivalent anaesthetic doses cause similar decreases in minute volume. ICI 35 868 decreased tidal volume to a greater extent than thiopentone. Whilst the time courses of the two drugs were similar in most respects, thiopentone produced a more prolonged increase in Pco2. This was accompanied by an increase in standard bicarbonate which was not seen in rabbits treated with ICI 35 868.

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