KANAMYCIN .1. TREATMENT OF PULMONARY TUBERCULOSIS

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Abstract
Seventeen patients with chronic pulmonary tuberculosis were treated with kanamycin in order to observe toxic effects and the development of microbial resistance to the drug. The therapeutic efficacy was studied in 19 patients with acute, previously untreated disease. A definite effect was observed, but probably less than that of either streptomycin or viomycin. The early loss of microbial susceptibility and the common occurrence of ototoxicity strictly limit the usefulness of the drug in the treatment of pulmonary tuberculosis. The possibility of preexisting renal disease constitutes a particular risk in connection with its use, because of the increase in the degree of impairment and the rapid development of ototoxicity under these circumstances. It is thought that the drug will be of most use in the early postoperative treatment of patients who harbor organisms resistant to the standard drugs.

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