Design and synthesis of 6α-substituted 2β,4α-dihydroxy-1β-phosphoryloxycyclohexanes, potent inhibitors of inositol monophosphatase
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 5,p. 298-300
- https://doi.org/10.1039/c39910000298
Abstract
Molecular superimposition studies have led to the design and synthesis of 2β,4α-dihydroxy-6α-[5-(2-hydroxyphenyl)pentyloxy]-1β-phosphoryloxycyclohexane, a potent inhibitor of inositol monophosphatase.Keywords
This publication has 12 references indexed in Scilit:
- Identification of (1S)-phosphoryloxy-(2R,4S)-dihydroxycyclohexane as a potent inhibitor of inositol monophosphataseJournal of the Chemical Society, Chemical Communications, 1990
- Inositol phosphates and cell signallingNature, 1989
- Synthesis of 2- and 6-deoxyinositol 1-phosphate and the role of the adjacent hydroxy groups in the mechanism of inositol monophosphataseJournal of the Chemical Society, Chemical Communications, 1989
- Purification and properties of myo-inositol-1-phosphatase from bovine brainBiochemical Journal, 1988
- The purification and properties of myo-inositol monophosphatase from bovine brainBiochemical Journal, 1988
- Ring formation by base-dependent isomerizations of epoxide-containing benzyl ethersThe Journal of Organic Chemistry, 1983
- Chemistry of higher order mixed organocuprates. 2. Reactions of epoxidesJournal of the American Chemical Society, 1982
- Organic reactions at alumina surfaces. Mild and selective opening of epoxides by alcohols, thiols, benzeneselenol, amines, and acetic acidJournal of the American Chemical Society, 1977
- Mild procedure for the conversion of epoxides to allylic alcohols. First organoselenium reagentJournal of the American Chemical Society, 1973
- Stereochemistry of the base-induced rearrangement of epoxides to allylic alcoholsJournal of the American Chemical Society, 1970