A Facile Synthesis of 5′-O,6-Cyclo-5,5-dihalogeno-5,6-dihydropyrimidine Nucleosides
- 1 January 1987
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1987 (09) , 829-831
- https://doi.org/10.1055/s-1987-28091
Abstract
Treatment of 2′,3′-O-isopropylidenepyrimidine nucleosides (1; uridine and cytidine) with excess N-halogenosuccinimides in an aprotic solvent at ambient temperature results in the exclusive formation of the corresponding 5′-O,6-cyclo-5, 5-dihalogeno-5,6-dihydro-2′,3′-O-isopropylidenepyrimidine nucleosides 2.Keywords
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