ON THE ELECTRON DONATING PROPERTIES OF CARCINOGENS

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Abstract
A number of substances were tested for their reaction time with iodine to determine whether there is an interrelation between carcinogenicity and the formation of a black complex with iodine, i.e., the ability to donate an electron to-a suitable local acceptor. All the strong carcinogens tested gave a black complex while their non-carcinogenic homologues did not. Apparently carcinogenicity of these substances is related to their ability to form strong charge transfer complexes with local acceptors and give off an electron. It is suggested that the "local" electron donation has to be backed up by a low P-valine (characterizing the energy of the highest filled orbital or the lowest empty orbital, in honor of the Pullmans) of the highest filled molecular orbital in order to lead to carcinogenicity.

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