Soluble Class 1 antigens (sHLA) in CSF and serum of patients with HIV infection
- 1 July 1990
- journal article
- research article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 82 (1) , 14-16
- https://doi.org/10.1111/j.1600-0404.1990.tb01580.x
Abstract
SHLA are secreted by B and T lymphocytes upon activation. These antigens are present in serum and cerebrospinal fluid (CSF). The establishment of a sHLA index, IH = (CSF sHLA/serum sHLA)/(CSF albumin/serum albumin) helped us to define that values above 9.7 reflect an intrathecal synthesis of these proteins. IH was significantly increased in a group of patients with intrathecal production of IgG against HIV-1 (HIV) and directly correlated with the synthesis of such antibodies. Therefore, IH seems to be an index of lymphocyte activation in CNS.Keywords
This publication has 10 references indexed in Scilit:
- Detection of soluble class i molecules (non hla‐a or hla‐b) in serum, spleen membranes and lymphocytes in cultureEuropean Journal of Immunology, 1989
- Soluble class I antigens in serum and CSF of patients with varicella-zoster virus meningitis.Journal of Neurology, Neurosurgery & Psychiatry, 1989
- Anti-HIV antibodies in the CSF of AIDS patients: a serological and immunoblotting study.Journal of Neurology, Neurosurgery & Psychiatry, 1988
- Quantification of soluble serum HLA Class I antigens in healthy volunteers and AIDS patientsClinica Chimica Acta; International Journal of Clinical Chemistry, 1988
- Detection of HTLV‐III‐specific IgG bands in the CSF from a patient with AIDS and encephalitisNeurology, 1988
- Secretion of HLA-A and -B antigens via an alternative RNA splicing pathway.The Journal of Experimental Medicine, 1986
- Intra-Blood–Brain-Barrier Synthesis of HTLV-III-Specific IgG in Patients with Neurologic Symptoms Associated with AIDS or AIDS-Related ComplexNew England Journal of Medicine, 1985
- Principles of albumin and IgG analyses in neurological disorders. I. Establishment of reference valuesScandinavian Journal of Clinical and Laboratory Investigation, 1977