Criticism of Tumor Response Criteria Raises Trial Design Questions
Open Access
- 15 February 2006
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 98 (4) , 232-234
- https://doi.org/10.1093/jnci/djj086
Abstract
When it debuted in 2000, the Response Evaluation Criteria in Solid Tumors (RECIST) was intended to be a simpler way to measure the response of tumors to experimental treatments. (See article, Vol. 92, No. 3, p. 205 .) The prior criteria, adopted by the World Health Organization in 1979, involved a complicated formula that required measuring two dimensions on a tumor and multiplying the parameters with a calculator, if not a computer. RECIST made the job easier by requiring measurements of just the longest dimension of several tumors and adding them together.Keywords
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