Alteration of the striatal dopaminergic system in human narcolepsy
- 10 June 2003
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 60 (11) , 1817-1819
- https://doi.org/10.1212/01.wnl.0000069608.84542.46
Abstract
Striatal D2/D3 dopaminergic receptors have been proposed to play a role in cataplexy. The authors studied the striatal presynaptic dopamine transporter and postsynaptic D2-receptors in seven patients with narcolepsy and seven control subjects using [123I](N )-(3-iodopropene-2-yl)-2β-carbomethoxy-3β-(4-chlorophenyl)tropane and [123I](S )-2-hydroxy-3-iodo-6-methoxy-([1-ethyl-2-pyrrolidinyl]methyl)benzamide SPECT. D2-Receptor binding was elevated in narcolepsy (p = 0.017) and correlated with the frequency of cataplectic and sleep attacks (R ≥ 0.844, p ≤ 0.017). The human striatal dopaminergic system is altered in vivo in narcolepsy/cataplexy.Keywords
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