Extensive editing of a small fraction of human T-cell leukemia virus type 1 genomes by four APOBEC3 cytidine deaminases
- 1 September 2005
- journal article
- Published by Microbiology Society in Journal of General Virology
- Vol. 86 (9) , 2489-2494
- https://doi.org/10.1099/vir.0.80973-0
Abstract
In the absence of the human immunodeficiency virus type 1 (HIV-1) Vif protein, the host-cell cytidine deaminases APOBEC3F and -3G are co-packaged along with virion RNA. Upon infection of target cells, nascent single-stranded DNA can be edited extensively, invariably giving rise to defective genomes called G→A hypermutants. Although human T-cell leukemia virus type 1 (HTLV-1) replicates in the same cell type as HIV-1, it was shown here that HTLV-1 is relatively resistant to the antiviral effects mediated by human APOBEC3B, -3C, -3F and -3G. Nonetheless, a small percentage of genomes (0·1<fin vitro, they are conspicuously absent in vivo.Keywords
This publication has 39 references indexed in Scilit:
- Cytidine Deamination of Retroviral DNA by Diverse APOBEC ProteinsCurrent Biology, 2004
- Comparison of the Differential Context-dependence of DNA Deamination by APOBEC Enzymes: Correlation with Mutation Spectra in VivoJournal of Molecular Biology, 2004
- DNA Deamination Mediates Innate Immunity to Retroviral InfectionCell, 2003
- Hypermutation of HIV-1 DNA in the Absence of the Vif ProteinScience, 2003
- RNA Editing Enzyme APOBEC1 and Some of Its Homologs Can Act as DNA MutatorsMolecular Cell, 2002
- A Chimeric Human T-Cell Lymphotropic Virus Type 1 with the Envelope Glycoprotein of Moloney Murine Leukemia Virus Is Infectious for Murine CellsJournal of Virology, 2002
- Human Immunodeficiency Virus Type 1 DNA Sequences Genetically Damaged by Hypermutation Are Often Abundant in Patient Peripheral Blood Mononuclear Cells and May Be Generated during Near-Simultaneous Infection and Activation of CD4 + T CellsJournal of Virology, 2001
- Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infectionNature, 1995
- A New Type of G→A Hypermutation Affecting Human Immunodeficiency VirusAIDS Research and Human Retroviruses, 1993
- Human infection by genetically diverse SIVSM-related HIV-2 in West AfricaNature, 1992