Pathophysiology of Generalized Photosensitive Epilepsy in the Cat
- 1 February 1984
- Vol. 25 (1) , 61-69
- https://doi.org/10.1111/j.1528-1157.1984.tb04156.x
Abstract
Feline generalized penicillin-induced epilepsy is a reliable experimental model of epileptic photosensitivity. Binocular photic stimulation at 4-8 flashes/s consistently triggers generalized, bilaterally synchronous spike-and-wave discharges in cats submitted to long-term i.m. penicillin administration at low dosage (50,000-150,000 IU/kg). The photically induced epileptic activity is 1st and mainly recorded from the cerebral cortex as compared with the lateral geniculate (GL) body, supporting a cortical onset of epileptic photosensitivity. At this low penicillin dosage, only minimal spontaneous spike-and-wave activity is recorded. Bilateral GL stimulation is more effective than binocular photic stimulation in triggering spike-and-wave discharges, whereas unilateral GL stimulation is grossly ineffective. A role of bilateral specific visual thalamocortical volleys in the genesis of epileptic photosensitivity is implied. Of 12 randomly selected cats receiving long-term penicillin 5 exhibited spontaneous epileptic photosensitivity. An underlying genetic predisposition of the feline species to this condition is suggested.Keywords
This publication has 31 references indexed in Scilit:
- Pathophysiology of generalized penicillin epilepsy in the cat: the role of cortical and subcortical structures. II. Topical application of penicillin to the cerebral cortex and to subcortical structuresElectroencephalography and Clinical Neurophysiology, 1977
- Generalized Spike and Wave Discharges: A Consideration of Cortical and Subcortical Mechanisms of Their Genesis and SynchronizationPublished by Springer Nature ,1972
- Light-induced epilepsy in the baboon, Papio Papio: Cortical and depth recordingsElectroencephalography and Clinical Neurophysiology, 1968
- Photosensitive epilepsy: Relationships between the visual evoked responses and the epileptiform discharges induced by intermittent photic stimulationElectroencephalography and Clinical Neurophysiology, 1967
- An animal model of light sensitive epilepsyElectroencephalography and Clinical Neurophysiology, 1967
- Color as a factor in light‐sensitive epilepsyNeurology, 1965
- Usefulness of photic stimulation in routine clinical electroencephalographyNeurology, 1960
- Some observations on the mechanism of photic and photo-metrazol activationElectroencephalography and Clinical Neurophysiology, 1952
- An experimental study of the mechanism of photic activation in idiopathic epilepsyElectroencephalography and Clinical Neurophysiology, 1950
- Combined photic and metrazol activation of the brainElectroencephalography and Clinical Neurophysiology, 1950