Time-related effects of benzodiazepines on intestinal motility in conscious dogs
- 1 February 1984
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 36 (2) , 130-132
- https://doi.org/10.1111/j.2042-7158.1984.tb03012.x
Abstract
The effects of diazepam and GABA on intestinal motility were investigated in fasted dogs fitted with strain‐gauge transducers. Injected intravenously at 9.00 and 16.00 h, diazepam (0·5 mg kg−1) affected intestinal motility only during darkness i.e. from 19.00 to 7.00 h. These jejunal motor effects which were mimicked by GABA, (0·3 mg kg−1 i.v.) corresponded to a disruption of the migrating myoelectric complex (MMC) with an increased contractile activity. These results demonstrate that benzodiazepines affect the intestinal motility in dog and suggest that the effects are related to sleep‐stages.Keywords
This publication has 13 references indexed in Scilit:
- Central Regulation of Intestinal Motility by Somatostatin and Cholecystokinin OctapeptideScience, 1982
- γ-Aminobutyric acid stimulates intrinsic inhibitory and excitatory nerves in the guinea-pig intestineEuropean Journal of Pharmacology, 1980
- Receptors for the Age of Anxiety: Pharmacology of the BenzodiazepinesScience, 1980
- Molecular Mechanisms in the Receptor Action of BenzodiazepinesAnnual Review of Pharmacology and Toxicology, 1979
- Secretory and motor activities at the gastroduodenal junction in dogsVeterinary Research Communications, 1979
- GABAergic modulation of benzodiazepine binding site sensitivityNature, 1978
- Rate of flow of digesta and electrical activity of the small intestine in dogs and sheep.The Journal of Physiology, 1975
- The effects of premedication drugs on the lower oesophageal high pressure zone and reflux status of rhesus monkeys and man.Gut, 1975
- Inhibitory effect of bromazepam on basal and betazole-stimulated gastric acid secretion in manGut, 1974
- The effect of diazepam on human gastric secretionGut, 1971