Adjuvant Effects of a Crystalline Silica on IgE and IgG1 Antibody Production in Mice and Their Prevention by the Macrophage Stabilizer Poly-2-Vinylpyridine N-Oxide
- 1 January 1983
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 71 (3) , 279-281
- https://doi.org/10.1159/000233404
Abstract
A crystalline silica (standard quartz DQ12 with particle size <5μm) is able to stimulate in Balb/c mice the production of IgE and IgG1 antibody to a single 1-μg dose of ovalbumin. The adjuvant effects of silica on both IgE and IgG1 antibody production are prevented by pretreatment of animals with poly-2-vinylpyridine N-oxide, a polymer that protects macrophages from the well-documented toxic effects of silica. These results indicate that adjuvanticity of silica is, at least partly, correlated to the damage induced on macrophages.Keywords
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