Elimination rates of selected di‐Ortho, mono‐ortho, and non‐ortho substituted polychlorinated biphenyls in rainbow trout (oncorhynchus mykiss)

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Abstract
In order to determine the influence of chlorine substitution pattern on elimination rate constants for polychlorinated biphenyls (PCBs), 60 rainbow trout (Oncorhynchus mykiss) were intraperitoneally injected with corn oil spiked with a mixture of 13 tetra‐ to hexachlorobiphenyls. The mixture consisted of four di‐ortho congeners (International Union of Pure and Applied Chemistry no. 52, 47, 101, and 153), five mono‐ortho congeners (66, 105, 118, 119, and 156), and four non‐ortho congeners (81, 77, 126, and 169). The range in growth‐corrected elimination rate constants for the non‐ortho‐substituted PCBs was 0.003 to 0.015 μg/kg per d. The range of elimination rate constants for the mono‐ortho PCBs was 0.007 to 0.012 μg/kg per d, and the range for the di‐ortho PCBs was 0.004 to 0.011 μg/kg per d. Multivariate analysis of covariance revealed a highly significant interaction between chlorine substitution pattern and time (p < 0.001), suggesting that substitution pattern influences elimination kinetics. Kow and time also revealed a significant interaction (p < 0.001). As structure can influence rates of chemical elimination, exposure dynamics of PCBs are a function of both hydrophobicity and substitution patterns. The study confirms the observation that the predicted rate of decline of some of the more toxic non‐ortho PCBs might be less than that observed for total PCBs.

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