Effect of Choline as a Lipotropic Agent in the Treatment of Human Coronary Atherosclerosis.

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Abstract
Clinical and exptl. observations on the action of choline in preventing or mitigating exptl. atherosclerosis have suggested that this lipotropic agent, like its fellow members of the vitamin B complex, inositol, pyridoxine, and methionine, appears to prevent arterial atheromatous deposition or to exert a decholesterolizing effect on the atheromatous deposits in the vascular walls of man and exptl. animals. Over a 3-yr. period the lipotropic agent choline was effective in significantly reducing the mortality rate due to recurrent coronary thrombosis with myocardial infarction in a series of 115 patients with proven coronary atherosclerosis.