Entry of Bilirubin into the Brain Due to Opening of the Blood-Brain Barrier
- 1 March 1982
- journal article
- research article
- Published by American Academy of Pediatrics (AAP) in Pediatrics
- Vol. 69 (3) , 255-259
- https://doi.org/10.1542/peds.69.3.255
Abstract
A potential animal model of kernicterus has been developed. The blood-brain barrier was opened on one side of the brain, by brief infusion of a hypertonic solution into the carotid artery. Upon peripheral infusion of bilirubin, the animals developed unilateral yellow staining of the brain: the treated side was stained whereas the control side was not. This cerebral icterus resulted from the entry of albumin-bound bilirubin into the brain, and not from the passage of free bilirubin.Keywords
This publication has 1 reference indexed in Scilit:
- Kernicterus in asphyxiated newborn rhesus monkeysExperimental Neurology, 1964