CONCOMITANT ADMINISTRATION OF GRANULOCYTE TRANSFUSIONS AND AMPHOTERICIN-B IN NEUTROPENIC PATIENTS - ABSENCE OF SIGNIFICANT PULMONARY TOXICITY

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 57  (1) , 90-94
Abstract
Series of granulocyte transfusions (195) in 144 patients were evaluated with respect to possible severe pulmonary toxicity from concomitant administration of granulocytes and amphotericin B. Dyspnea as a side effect of granulocyte transfusion was equally common among patients receiving amphotericin B and those in a matched control group not receiving amphotericin B. Granulocyte transfusions and amphotericin B were given simultaneously in 35 transfusion series involving 32 patients. Respiratory deterioration, defined as the appearance of new pulmonary infiltrates on chest X-ray, occurred in 11 of these 35 episodes. Patients developing respiratory deterioration were similar to those not developing respiratory deterioration in age, diagnosis, disease status, concomitant therapy duration and outcome but more often had positive fungal cultures as an indication for treatment (91% vs. 58%; P = 0.1). In 8 patients, the respiratory deterioration episodes were readily explained by congestive heart failure, by simultaneous bacteremia or fungemia or by fungal pneumonia discovered at autopsy. One patient had a leukoagglutinin reaction (responsive to steroids) and the other 2 had unexplained but reversible respiratory deterioration. Evidently, concomitant administration of granulocyte transfusions and amphotericin B is not associated with unexpected or rapidly fatal pulmonary toxicity and when appropriate can be safely accomplished.

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