Ionic Fluoride: A Study of its Physiological Variation in Man

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Abstract
The serum ionic fluoride concentrations in 497 normal individuals, from areas with non-fluoridated water supplies, ranged from 0·25 to 2·20 μmol F−/l and were positively correlated with age (r = 0·31, p<0·001). Distribution of the data with age, coupled with the distribution of serum calcium with age, suggests a possible change in bone metabolism between 26 and 35 years of age. Serum fluoride levels vary with the time of day with a mean minimum value at 0800 and a mean peak value at 2200. Renal clearance studies gave fluoride ion clearances ranging from 19·5 to 44·0 ml/min and tubular reabsorption of fluoride ion ranging from 61·5 to 86·5%. After oral ingestion of 0·48 mmol sodium fluoride, peak serum levels occurred at 60 to 90 minutes; the peak levels were significantly higher in women than in men.

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