TTP — Desperation, Empiricism, Progress

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Abstract
Wendell Rosse of the Duke University Medical Center once remarked about paroxysmal nocturnal hemoglobinuria that "more people study the disease than have it." Another uncommon disorder, thrombotic thrombocytopenic purpura (TTP), is the subject of two articles in this issue of the Journal.1 , 2 First described by Moschcowitz in 1924, the illness has fascinated physicians with its dramatic clinical presentations, high mortality rate, and more recently, the effectiveness of empirical therapy.3 The platelet aggregates in thrombotic thrombocytopenic purpura produce fluctuating ischemia or infarction in various organs, including the brain in 50 to 71 percent of the episodes.1 , 2 In the closely related . . .

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