GALLSTONE DISSOLUTION BY CHENODEOXYCHOLIC ACID AND PHENOBARBITAL

  • 1 January 1978
    • journal article
    • research article
    • Vol. 69  (2) , 160-165
Abstract
Gallstone dissolution and biliary lipids were determined and compared in patients receiving either chenodeoxycholic acid (CDC), or CDC and phenobarbital (PB) for 1 1/2 to 2 yr. Among patients with radiolucent gallstones, dissolution occurred in 53% of those receiving CDC alone and in only 25% of those receiving both CDC and PB. No dissolution occurred in 13 other patients with calcified gallstones. Patients with dissolution had a significantly greater molar percentage of CDC and a significantly lower saturation index in bile than those without dissolution. Diarrhea and transiently abnormal liver function tests were the most frequently observed side-effects but only diarrhea necessitated a reduction of the CDC dose. Gallstones recurred following dissolution in 1 of 6 patients followed for 6 mo. after discontinuation of CDC. PB did not enhance CDC-induced desaturation of bile or gallstone dissolution.

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