DNA Cleavage Induced by Thermal Electron Transfer from a Dimeric NADH Analogue to Acridinium Ions in the Presence of Oxygen
- 21 September 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 126 (40) , 12794-12795
- https://doi.org/10.1021/ja046955p
Abstract
Acridinium ions, which can intercalate to DNA, act as thermal DNA cleavers in the presence of a dimeric NADH analogue and O2 in an aqueous solution via thermal electron transfer from a dimeric NADH analogue to acridinium ions, followed by the electron-transfer reduction of O2 to O2•- by the resulting NAD radicals.Keywords
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