ANTIOXIDANTS AS AGENTS POTENTIATING ANTIINFLAMMATORY ACTION OF INDOMETHACIN

  • 1 January 1976
    • journal article
    • research article
    • Vol. 35  (11) , 1547-1551
Abstract
Nordihydroguaiaretic acid inhibits prostaglandin (PG) biosynthesis in vitro [bovine seminal vesicle microsomes] (ID50 [median inhibitory dose] = 228 .mu.M), with a slope of dose-response curve high (b = 209) as compared with indomethacin (ID50 = 0.1 .mu.M, b = 72.1). Butylated hydroxyanisole, in contrast to inactive butylated hydroxytoluene, inhibits PG biosynthesis (ID50 = 107 .mu.M, b = 63). Only nordihydroguaiarectic acid (100 .mu.g, s.p. [subplantar]) inhibited the postcarrageenan edema of rat paw. Butylated hydroxyanisole (10 .mu.g, s.p.) given together with a subthreshold (1 .mu.g) dose of indomethacin inhibited the paw edema by 35%, while butylated hydroxytoluene and nordihydroguaiaretic acid produced a similar effect only when given at 10-fold higher doses. The possibility of potentiation and prolongation of the anti-inflammatory effect of indomethacin by its simultaneous administration with an antioxidant, butylated hydroxyanisole is suggested.

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