Effect of truncated glucagon‐like peptide 1 on cAMP in rat gastric glands and HGT‐1 human gastric cancer cells
- 15 August 1988
- journal article
- Published by Wiley in FEBS Letters
- Vol. 236 (1) , 119-122
- https://doi.org/10.1016/0014-5793(88)80297-7
Abstract
We tested the truncated 7–37 glucagon‐like peptide 1 (TGLP‐1), a naturally occurring porcine intestinal peptide, and other members of the glucagon family, including pancreatic glucagon (G‐29), GLP‐1 and GLP‐2 for their ability to activate the cAMP generating system in rat gastric glands and HGT‐1 human gastric cancer cells. In rat fundic glands, TGLP‐1 was about 100 times more potent (EC50 = 2.8 × 10−9M) than GLP‐1 of G‐29, and 10 times more potent than G‐29 in the HGT‐1 cell line. Our results support the notion that TGLP‐1 plays a direct role in the regulation of acid secretion in rat and human gastric mucosa.Keywords
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