Synthesis, iron(II)-induced cleavage and in vivo antimalarial efficacy of 10-(2-hydroxy-1-naphthyl)-deoxoqinghaosu (-deoxoartemisinin)
- 1 January 1999
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 13,p. 1827-1832
- https://doi.org/10.1039/a902086a
Abstract
A convenient methodology for attaching an acid-stable UV chromophore onto the qinghaosu (artemisinin) framework with readily available dihydroqinghaosu acetate as the starting material is presented. The resulting derivatives of deoxoqinghaosu may be used as a sensitive probe in the mechanistic and biological/pharmacological investigations. As the first application of the present methodology, naphth-2-ol is attached to qinghaosu nucleus through a carbon–carbon single bond by a boron trifluoride-catalyzed Friedel–Crafts alkylation. A previously undetected racemization at C-9 mediated by an enol ether under the reaction conditions (BF3·OEt2, CH2Cl2) that have been widely used for preparing C-10 derivatives of dihydroqinghaosu is observed. The knowledge gained from the present work may assist the rational design of new trioxane-type antimalarial agents.Keywords
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