The effects of nifedipine on blood flow in peripheral vascular disease of the lower limbs

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Abstract
The effects of nifedipine on blood flow to the lower limb have been investigated in 19 patients with calf claudication, and in 8 patients with critical leg ischaemia, using Doppler techniques. In claudicants, common femoral artery blood flow increased by 55% after sublingual nifedipine, despite a fall in systolic blood pressure and no alteration in the ankle/brachial index. In patients with critical ischaemia given intravenous nifedipine, common femoral blood flow increased to reach a peak 90 minutes after the start of the infusion. The femoral artery pulsatility index, derived from the Doppler waveform, is a reliable guide to changes in blood volume flow.

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