EFFECT OF GONADOTROPIC SUBSTANCE ON OVULATION

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Abstract
A gonadotropic substance is one that stimulates the growth and hormonal function of the epithelial elements of the ovary. Gonadotropic substances have been isolated from various fluids and tissues of the body, such as pregnancy blood serum, spinal fluid, castrate and postmenopausal urine, from the pituitary gland and from the placenta. They have been demonstrated to have two functions: one is stimulation of growth of the follicle and the other is the induction of ovulation and luteinization of the follicle. Gonadotropic substances vary considerably in their ability to stimulate the ovary. Although the characteristic activities have been demonstrated in experimental animals, results obtained with the use of these substances in the human female have not been as satisfactory.1 Most of the reports indicate that of the many known gonadotropic substances, the one obtained from pregnant mare serum is probably the most effective in stimulating the human ovary. Reports that

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