TREATMENT OF HYPERTENSIVE PATIENTS WITH RAUWOLFIA COMPOUNDS AND RESERPINE
- 17 December 1955
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 159 (16) , 1513-1516
- https://doi.org/10.1001/jama.1955.02960330013004
Abstract
Recently Freis1described five cases in which mental depression was observed in hypertensive patients treated with reserpine (Serpasil). The purpose of this report is to describe four more hypertensive patients, two in detail, who were treated with a Rauwolfia alkaloid or reserpine. Mental depression was observed in three of the patients, whereas in the fourth case the diagnosis was a psychotic reaction. REPORT OF CASES Case 1.— A 54-year-old married white woman, a veteran, was admitted to the hospital on Nov. 12, 1954, for evaluation of her hypertension and depressive reaction. During a routine physical examination in 1944, she had been found to have hypertension and since then had been treated with cortical depressants such as phenobarbital. In May, 1954, she had been placed on therapy with reserpine, 0.25 mg. four times a day. During the summer she had noticed considerable nasal stuffiness. Her mean blood pressure was 160/105Keywords
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