INHIBITION OF VASOCONSTRICTOR RESPONSES BY PROSTACYCLIN (PGI2) IN THE FELINE MESENTERIC VASCULAR BED

  • 1 January 1979
    • journal article
    • research article
    • Vol. 241  (2) , 214-223
Abstract
The effects of infusion of prostacyclin, PG[prostaglandin]I2, on vasoconstrictor responses to sympathetic nerve stimulation, norepinephrine and angiotensin II were studied in the mesenteric vascular bed of the cat. Stimulation of the sympathetic nerves and intra-arterial injections of norepinephrine and angiotensin increased mesenteric perfusion pressure in a frequency and dose-dependent manner. Responses to nerve stimulation and pressor hormones were reproducible and not altered by infusions of the Tris vehicle for PGI2 or the PGI2 breakdown product, 6-keto-PGF1.alpha.. Infusions of PGI2, 1 and 0.3 .mu.g/min, decreased mesenteric arterial perfusion pressure and at the higher infusion rate markedly reduced responses to nerve stimulation, norepinephrine and angiotensin. At the lower infusion rate PGI2 casued small but significant reductions in responses to norepinephrine and nerve stimulation but did not alter responses to angiotensin. PGI2 has the ability to inhibit vasoconstrictor responses in the feline intestinal vascular bed and apparently this effect is postjunctional.

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