In Vitro Response of Blastocystis hominis to Antiprotozoal Drugs

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Abstract
Ten antiprotozoal drugs were tested in vitro against 4 axenic strains of the intestinal parasite B. hominis. Inhibitory drugs in order of effectiveness were emetine, metronidazole, furazolidone, trimethoprim sulfamethoxazole, 5-chloro-8-hydroxy-7-iodo-quinoline (Entero-Vioform) and pentamidine. Moderately inhibitory were 2 quinolines other than iodochlorhydroxquin. These were chloroquine and 5,7-diiodo-8-hydroxy-quinoline (Floraquin). Diloxanide furoate was not inhibitory. Paromomycin and other antibiotics were not inhibitory. Entero-Vioform and metronidazole have been effective in human and higher primate diarrhea caused by B. hominis.