HISTAMINE SYNTHESIS, IMIDAZOLE DIPEPTIDES, AND WOUND-HEALING

  • 1 January 1982
    • journal article
    • research article
    • Vol. 91  (4) , 430-434
Abstract
The relationships among anserine (.beta.-alanyl-1-methyl-L-histidine), carnosine (.beta.-alanyl-L-histidine), free histidine and histamine metabolism were examined in rats wounded by dorsal skin incision. Following wounding, rats were treated with either a histamine liberator (compund 48/80 [4-methoxy-N-methylbenzene ethanamine]) or a histidine decarboxylase inhibitor (4-imidazolyl-3-amino-2-butanone). The liberator greatly enhanced wounded skin-breaking strength and collagen deposition at the wound site, while the histidine decarboxylase inhibitor reduced skin-breaking strength and collagen deposition. In the 2nd experiment, histamine or histidine treatment prevented trauma-induced reductions of tissue carnosine but was less effective in ameliorating tissue anserine loss. The results illustrate an interaction between imidazole dipeptides and stress and suggest that carnosine acts as a histidine reserve in relation to histamine synthesis during trauma.

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