Genetic and biochemical studies of phosphomannose isomerase deficient mutants ofSaccharomyces cerevisiae
- 1 March 1976
- journal article
- research article
- Published by Springer Nature in Molecular Genetics and Genomics
- Vol. 144 (2) , 223-230
- https://doi.org/10.1007/bf02428113
Abstract
Three mannose-negative mutants ofSaccharomyces cerevisiae have been isolated. These mutants showed growth inhibition when mannose was added to a growth medium containing glycerol or fructose. Crosses between wild type mutants showed segregation of 2+/2−. Crosses between the mutants themselves showed that they were closely linked. Two mutants (XM3 and D2) showed characteristics of allelic structural alteration of phosphomannoseisomerase. Mutant D4 had a deficiency of phosphomannoseisomerase activity, but with a normal thermostability. Revertants from D4 had a normal thermostability.This publication has 35 references indexed in Scilit:
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