Histological changes in the thyroid gland of the mouse following treatment with 1, 1,3-tricyano-2-amino-1-propene

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Abstract
1,1,3-tricyano-2-amino-l-propene (malononitrile dimer), administered intraperitoneally to mice, induced histological changes in the thyroid gland 6 h after drug administration. The histology of the thyroid gland is normal up to 16 h after drug treatment. Pathological conditions characteristic of hyperthyroidism are observed after 16 h of the drug treatment. By 48 h, the thyroid again appeared normal. The antithyroid action of the drug is attributed to the initial acute inhibition of the organic binding of iodine causing supression in the formation of thyroxine, which is later compensated.