Phenytoin dosage in ambulant epileptic patients.

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Abstract
Ambulant patients with recently diagnosed generalized or psychomotor seizure disorders or both were randomly assigned to 2 dosage regimens of phenytoin. Drug compliance was evaluated with subsequent blood phenytoin levels 4-8 wk after initial enrollment into the study. Although the 2 groups had similar mg-kg daily dosages of phenytoin, the mean blood levels were statistically different between the 2 groups, favoring the simplified dosage regimen. Once or twice a day dosage regimens of phenytoin had a beneficial effect on drug compliance when compared to more frequent regimens as measured by phenytoin blood levels.